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March 16, 2005


Sleep-Disordered Breathing May Have an Adverse Effect on the Neurocognitive Development in Young Children

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A study on the effects of snoring in young children found that there was a strong link between frequent snoring and sleep apnea, and various impairments on various cognitive and intellectual abilities.

Past studies have found snoring to be present in 18% to 20% of infants, 7% to 13% of children from 2 to 8 years of age, and 3% to 5% of older children. Sleep Disordered Breathing (SDB) can range from mild snoring to Obstructive Sleep Apnea (OSA), characterized by frequent obstruction of the air passageway resulting in interrupted sleep, frequently leading to functional sleep deprivation.

Cardiovascular disease is one known long-term effect of SDB; however a lesser known consequence appears to be diminished neurocognitive function. In adults, untreated SDB leads to impairments of fine visual and motor coordination and of sustained attention and concentration deficits. Furthermore, MRIs have shown that the parts of the brain affected by SDB indicate early-onset deficits.

This study adds to current research on mild SDB in children and frequent neurobehavioral disorders such as learning and cognitive deficits, and behavioral problems such as attention deficit and hyperactivity.


Methods

A broad range of neurocognitive tests were used in a sample of 5-year-old children. The researchers implemented a population-derived sample—meaning that the participants of the study were randomly selected from the general population—as opposed to being a referral-based cohort—a group referred by a clinic or health care practitioners.


Results

30% of the children were found to have symptoms of SDB. Also, there was a relationship between these symptoms (snoring, loud breathing during sleep, and sleep apnea) and damaged behavioral control and impaired memory and other intellectual capacities.

Furthermore, these findings remained even after removing data for 8 children whose symptoms were more severe.

Conclusion

The findings of this study suggest that neurocognitive impairments are only associated with mild symptoms of SDB, namely, “benign” snoring, or borderline obstructive sleep apnea (OSA).

This study’s strengths included the use of a population-based cohort and the implementation of state-of-the-art neurocognitive tests, enabling researchers to more clearly distinguish between various levels of SDB; however, there are several limitations to this study as well.

Researchers of this study did not include demographic information, such as: income/education level, race, ethnicity, various sleep patterns, and body mass index. Furthermore, in order to determine the causes of SDB and the disorder’s relationship to neurocognitive deficiencies, additional longitudinal studies will be needed to assess children in their preschool years.

There are further implications that upper airway resistance related to snoring and noisy breathing may lead to poor school performance in children. Additional studies will be required to determine how to best assess this risk and to define the age and means by which to intervene to avoid long-term neurocognitive dysfunction.

Complete findings of the study appear in Journal of Pediatrics, October 2004; 145: pp. 430-32

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